No Association between CALHM1 and Alzheimer's Disease Risk
نویسندگان
چکیده
منابع مشابه
No Association between CALHM1 and Alzheimer's Disease Risk
In a recent paper in Cell, Dreses-Wer-ringloer et al. (2008) reported the identification and functional characterization of a new Alzheimer's disease (AD) gene, CALHM1, encoding calcium homeostasis modulator 1. CALHM1 (formerly annotated as FAM26C) represents a compelling candidate gene for late-onset AD as it is located on chromosome 10q24, a consistently replicated AD linkage region (Bertram ...
متن کاملResponse: CALHM1 Association with Alzheimer's Disease Risk
ranging from 0.15 to 0.84). Stratification by age of AD onset (using 65 years as cutoff) or APOE ε4-genotype did not appreciably change these results (data not shown; stratified analyses were not possible in the GWAS samples as no onset age or APOE ε4 data were supplied). Effect size estimates indicated insignificant ORs that were opposite in direction to those reported by Dreses-Werringloer et...
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Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics [D. S. M., D. A.] and Center for Cancer Research [T. J. H., P. R. T.], National Cancer Institute, Rockville, Maryland 20852; Pennsylvania State University, University Park, Pennsylvania 16802 [T. J. H.]; and Department of Epidemiology and Health Promotion, National Public Health Issue, Helsinki, Finland [P. P., G. A.,...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.11.030